Delirium as an atypical presenting symptom of systemic lupus erythematosus

Authors

  • Patricia Fanlo-Mateo Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Complejo Hospitalario de Navarra, Pamplona, Spain
  • Vanesa Antoña-Sáenz Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Complejo Hospitalario de Navarra, Pamplona, Spain
  • Amaia Redondo-Arriazu Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Complejo Hospitalario de Navarra, Pamplona, Spain
  • Fernando Pérez-Nievas Servicio de Psiquiatría, Complejo Hospitalario de Navarra, Pamplona, Spain
  • Laureano Menéndez-Ozcoidi Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Complejo Hospitalario de Navarra, Pamplona, Spain

DOI:

https://doi.org/10.32818/reccmi.a2n3a5

Keywords:

systemic lupus erythematosus, antiphospholipid antibodies, neuropsychiatric lupus, delirium

Abstract

Systemic lupus erythematosus is a multisystem autoimmune disease that can affect the central and peripheral nervous system in the form of neuropsychiatric lupus. Up to 95% of patients will be able to develop neuropsychiatric lupus at any time of the disease. Multiple factors (autoantibodies, microvascular disease and proinflammatory cytokines) have been associated with its pathogenesis. The diagnosis of neuropsychiatric lupus poses a challenge for the clinician, since the diagnosis will only be achieved once other causes have been ruled out. The management of this pathology is based on the symptomatic treatment associated or not with immunosuppressants.

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References

Unterman A, Nolte JE, Boaz M, et al. Neuropsychiatric syndromes in systemic lupus erythematosus: A meta-analysis. Semin Arthritis Rheum. 2011; 41: 1-11.

The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum.1999; 42: 599-608.

Hermosillo–Romo D, Brey RL. Diagnosis and management of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Best. Practice and Research Clinical Rheumatology. 2002; 16: 229-244.

Sommerlad A, Duncan J, Lunn MPT, et al. Neuropsychiatric systemic lupus erythematosus: a diagnosis challenge. BMJ Case Rep. 2015; 5.

Heckman GA, Papaioannou A, Adachi JD, et al. Systemis Lupus Eryrhematosus presenting as subacute delirium in a 82-year-old woman. JAGS. 2001; 49: 458-461.

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Published

2017-12-31

How to Cite

1.
Fanlo-Mateo P, Antoña-Sáenz V, Redondo-Arriazu A, Pérez-Nievas F, Menéndez-Ozcoidi L. Delirium as an atypical presenting symptom of systemic lupus erythematosus. Rev Esp Casos Clin Med Intern [Internet]. 2017 Dec. 31 [cited 2024 May 11];2(3):116-8. Available from: https://www.reccmi.com/RECCMI/article/view/191

Issue

Vol. 2 No. 3 (2017): Spanish Journal of Case Records in Internal Medicine

Section

CLINICAL CASES

License

Copyright (c) 2017 Patricia Fanlo-Mateo, Vanesa Antoña-Sáenz, Amaia Redondo-Arriazu, Fernando Pérez-Nievas, Laureano Menéndez-Ozcoidi

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