Síndrome de Cushing ectópico secundario a carcinoma microcítico pulmonar

Víctor Urbaneja-Zumaquero; Daniel  de la Cueva-Genovés; Daniel Ávila-Royón

doi:10.32818/reccmi.a11n1a10

Authors

Víctor Urbaneja-Zumaquero Internal Medicine Department, Virgen de la Victoria University Hospital, Málaga, Spain https://orcid.org/0009-0007-0182-7375
Daniel de la Cueva-Genovés Internal Medicine Department, Virgen de la Victoria University Hospital, Málaga, Spain
Daniel Ávila-Royón Internal Medicine Department, Virgen de la Victoria University Hospital, Málaga, Spain https://orcid.org/0009-0004-9066-3875

DOI:

https://doi.org/10.32818/reccmi.a11n1a10

Keywords:

Cushing syndrome, ectopic ACTH syndrome, small cell lung carcinoma, neuroendocrine tumors, hypokalemia

Abstract

Ectopic Cushing's syndrome is rare. We present a 54-year-old woman with weakness, edema, and refractory hypertension.
Severe hypokalemia and hypercortisolism were identified, caused by a metastatic ACTH-producing small-cell
lung carcinoma. She was treated with chemotherapy and ketoconazole. This case highlights how refractory hypokalemia
and alkalosis can be the first clinical manifestation of a highly aggressive hidden tumor, emphasizing the vital
need for early anti-cortisol therapy to stabilize the patient and allow for oncological treatment.

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