Spontaneous iliopsoas hematoma in a patient with moderate hemophilia B

Authors

  • Ana Xcaret Tisnado-Quevedo Emergency Medicine Service, Regional General Hospital 110 IMSS, Guadalajara, Jalisco, Mexico
  • Antonio Osuna-López Internal Medicine Service, UMAE Specialty Hospital, National Medical Center of the West IMSS, Guadalajara, Jalisco, Mexico
  • Rigoberto Castillo-Leva Internal Medicine Service, UMAE Specialty Hospital, National Medical Center of the West IMSS, Guadalajara, Jalisco, Mexico
  • Daniela Páez-Lizárraga Internal Medicine Service, General Hospital of the State of Sonora, Hermosillo, Sonora, Mexico

DOI:

https://doi.org/10.32818/reccmi.a10n3a17

Keywords:

hemophilia B, hematoma, psoas muscles

Abstract

Iliopsoas hematomas are a serious complication of hemophilia B. In this case, a patient with moderate hemophilia B and a factor IX activity level of 1.7% also had a spontaneous iliopsoas hematoma. Diagnosis was made using computed tomography (CT), and treatment consisted primarily of factor IX replacement at 40 IU/kg every 12 hours, reaching a target factor IX level of 65% by day 8 of the treatment regimen. This case highlights the importance of suspecting iliopsoas hematomas in patients with hemophilia who present with abdominopelvic pain. It is important to order CT or MRI scans and measure factor IX activity levels to confirm the suspicion and initiate factor IX replacement early. Furthermore, consultation with a surgical or interventional radiology service is recommended if the hematoma is refractory to medical treatment or if the patient presents with femoral neuropathy or compartment syndrome.

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References

Howdary P, Carcao M, Kenet G, Pipe SW. Haemophilia. Lancet. 2025; 405(10480): 736-50. doi: https://doi.org/10.1016/S0140-6736(24)02139-1 (último acceso dic. 2025). DOI: https://doi.org/10.1016/S0140-6736(24)02139-1

Sidonio RF Jr, Malec L. Hemophilia B (Factor IX Deficiency). Hematol Oncol Clin North Am. 2021; 35(6): 1143-55. doi: https://doi.org/10.1016/j.hoc.2021.07.008 (último acceso dic. 2025). DOI: https://doi.org/10.1016/j.hoc.2021.07.008

Rezende SM, Neumann I, Angchaisuksiri P, Awodu O, Boban A, Cuker A, et al. International Society on Thrombosis and Haemostasis clinical practice guideline for treatment of congenital hemophilia A and B based on the GRADE methodology. J Thromb Haemost. 2024; 22(9): 2629-52. doi: https://doi.org/10.1016/j.jtha.2024.05.026 (último acceso dic. 2025). DOI: https://doi.org/10.1016/j.jtha.2024.05.026

Rodriguez-Merchan EC. Complications of muscle hematomas in hemophilia. Cardiovasc Hematol Disord Drug Targets. 2020; 20(4): 242-48. doi: https://doi.org/10.2174/1871529X20666200415121409 (último acceso dic. 2025). DOI: https://doi.org/10.2174/22124063MTA13ODMnz

Rodriguez-Merchan EC, De la Corte-Rodriguez H. Iliopsoas hematomas in people with hemophilia: diagnosis and treatment. Expert Rev Hematol. 2020; 13(8): 781-89. doi: https://doi.org/10.1080/17474086.2020.1787146 (último acceso dic. 2025). DOI: https://doi.org/10.1080/17474086.2020.1787146

Garge S, Mahajan A, Atluri S, Baliyan V, Singh A, Jain S, et al. Role of endovascular embolization in treatment of acute bleeding complications in haemophilia patients. Br J Radiol. 2016; 89(1060): 20151064. doi: https://doi.org/10.1259/bjr.20151064 (último acceso dic. 2025). DOI: https://doi.org/10.1259/bjr.20151064

Wojciechowski J, Gaitonde P, Hughes JH, Ravva P. Population modeling of factor IX activity following administration of fidanacogene elaparvovec gene therapy in participants with hemophilia B. Clin Pharmacokinet. 2025; 64(10): 1531-48. doi: https://doi.org/10.1007/s40262-025-01443-0 (último acceso dic. 2025). DOI: https://doi.org/10.1007/s40262-025-01535-y

Published

2025-12-23

How to Cite

1.
Tisnado-Quevedo AX, Osuna-López A, Castillo-Leva R, Páez-Lizárraga D. Spontaneous iliopsoas hematoma in a patient with moderate hemophilia B. Rev Esp Casos Clin Med Intern [Internet]. 2025 Dec. 23 [cited 2026 Jan. 1];10(3):153-5. Available from: https://www.reccmi.com/RECCMI/article/view/1241