Anti-LGI1 autoimmune encephalitis: a diagnostic challenge

Authors

  • Javier Ramos-Lázaro Internal Medicine Service, Hospital de la Santa Creu i Sant Pau, Barcelona, ​​Spain https://orcid.org/0009-0009-1997-0430
  • Anna Borrás i Dorca Internal Medicine Service, Hospital de la Santa Creu i Sant Pau, Barcelona, ​​Spain https://orcid.org/0009-0007-6949-4810
  • Gerard Alba-Hernández Pneumology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, ​​Spain
  • Belén Sopena-Carrera Radiation Oncology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, ​​Spain

DOI:

https://doi.org/10.32818/reccmi.a11n1a5

Keywords:

autoimmune encephalitis, facio-brachio-crural dystonic crises, immunotherapy

Abstract

Autoimmune encephalitis is an increasingly recognized condition that causes subacute-onset behavioral or cognitive
disturbances. We present the case of a 78-year-old woman with recurrent falls, facio-brachio-crural dystonic
seizures, and emotional lability, initially diagnosed with conversion disorder in the context of bereavement. The
identification of anti-LGI1 antibodies confirmed the diagnosis of autoimmune encephalitis, with a good response
to corticosteroid therapy. This case underscores the importance of considering this condition in the differential
diagnosis, given its potential for reversibility with early treatment.

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References

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Published

2026-04-23

How to Cite

1.
Ramos-Lázaro J, Borrás i Dorca A, Alba-Hernández G, Sopena-Carrera B. Anti-LGI1 autoimmune encephalitis: a diagnostic challenge. Rev Esp Casos Clin Med Intern [Internet]. 2026 Apr. 23 [cited 2026 May 1];11(1):13-5. Available from: https://www.reccmi.com/RECCMI/article/view/1251

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